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Welche Ursachen gibt es für Autoimmunerkrankungen?

Autoimmun-Erkrankungen sind durch eine falsche Programmierung des menschlichen Abwehrsystems (Immunsystems) gekennzeichnet. Die eigenen Zellen und Organe werden bekämpft und führen so zu den unterschiedlichsten Krankheitserscheinungen. Wie es zu dieser Fehlprogrammierung kommt, ist bis heute noch nicht genau und im Detail geklärt.


Als mögliche Auslöser für die Fehlprogrammierung werden heute von außen kommende Ereignisse wie Virusinfekte, Medikamente oder eine immunologische Sondersituationen (z.B. eine Schwangerschaft) diskutiert.

Hat ein Infektionserreger zum Beispiel in seinen Bestandteilen eine hohe Ähnlichkeit mit der Struktur eines körpereigenen Gewebes, kann es dazu kommen, dass der Körper Abwehrkörper (Antikörper) bildet, die auch körpereigenes Gewebe angreifen. Ein bekanntes Beispiel ist das sogenannte “rheumatische Fieber“, ein Infekt durch Streptokokken, bei dem es zu Reaktionen gegen Herzmuskelgewebe kommt.


Ein anderer Erklärungsansatz bezieht sich auf die Fähigkeit des gesunden Organismus, körpereigene Bestandteile von fremden zu unterscheiden. Diese Fähigkeit wird „Immuntoleranz“ genannt. Verliert der Körper diese „Immuntoleranz“, wird das eigene Gewebe zum Opfer seiner eigenen Immunantwort. Die Gründe für diesen Toleranzverlust sind nur in Ansätzen bekannt. Möglicherweise werden „autoreaktive Zellen“ die sich wahrscheinlichen auch bei gesunden Personen finden, übermäßig aktiviert und führen damit zum Toleranzverlust.

Veranlagung und Vererbung

Es ist bekannt, dass bestimmte Autoimmun-Erkrankungen in einigen Familien gehäuft auftreten. Bislang finden sich in der wissenschaftlichen Literatur allerdings keine Hinweise darauf, dass Autoimmun-Erkrankungen direkt vererbt werden können. Wahrscheinlich ist, das es die Veranlagung ist, die weitergeben wird. Hieraus kann sich ein höheres Risiko für eine Autoimmun-Erkrankung ableiten, was aber nicht zu einer Erkrankung führen muss.


Die Funktion des menschlichen Abwehrsystems wird auch durch Umweltfaktoren beeinflusst. Daher ist es wahrscheinlich, dass Ausprägung und Schweregrad von Autoimmun-Erkrankungen auch von Umweltfaktoren beeinflusst werden. Über die zugrunde liegenden Mechanismen ist wenig bekannt.