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1. Entwicklung von Zelltherapien für Autoimmunerkrankungen

Projekt-Leiter:

Prof. Dr. med. Fred Fändrich, Klinik für Angewandte Zelltherapie
UKSH Campus Kiel (email: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!)

Prof. Dr. med. Dieter Kabelitz, Institut für Immunologie
UKSH Campus Kiel (email: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!)

Im Rahmen von Autoimmunerkrankungen kommt es zur fehlgesteuerten Immunantwort gegen körpereigene Zellen oder Antigene. Obwohl konventionelle immunsuppressive Medikamente bei vielen Autoimmunerkrankungen klinisch sehr wirksam sind, beeinflussen diese Medikamente das Immunsystem insgesamt und nicht nur die fehlgesteuerte Reaktivität gegen körpereigene Bestandteile. Aus immunologischer Sicht ist es wünschenswert, die verloren gegangene Toleranz gegenüber den körpereigenen Antigenen wieder herzustellen und damit die Autoimmunität zu beenden. In diesem Projekt entwickeln wir zellbasierte Strategien zur Therapie von Autoimmunerkrankungen. Eine Untergruppe von Makrophagen, die sogenannten M2 Makrophagen, zeichnen sich durch immunregulatorische Aktivität aus. M2 Makrophagen könne aufgrund ihrer Produktion von inhibitorischen Botenstoffen wie Transforming Growth Factor- und Interleukin-10 die Aktivierung von Immunzellen blockieren. Wir entwickeln Verfahren zur Herstellung und Charakterisierung dieser Zellen, die zunächst im Rahmen von Heilversuchen zur Behandlung von solchen Patienten eingesetzt werden sollen, bei denen konventionelle immunsuppressive Medikamente nicht (mehr) wirksam sind.


 

2. Innovative Analyse von Immunzell-Funktion bei Autoimmunerkrankungen

Projektleiter:

Prof. Dr. med. Dieter Kabelitz, Institut für Immunologie
UKSH Campus Kiel (email: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!